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FRIEDRICH WILIIELM KLEVER, OF COLOGNE, GERMANY, ASSIGNOR TO EDWARD THEODORE PEARSON, OF HAMBURG, GERMANY.

OlNTMENT BASE AND METHOD OF MAKING SAME.

SPECIFICATION forming part of Letters Patent No. 608,612, dated August 9, 1898.

Application filed. December 13, 1897.' Serial No. 661,713.

(No specimens.) Patented in England June 24, 1893, No. 12,446,

and February 26, 1897,110. 5,256; in Belgium June 26, 1893,1To. 105,269; in Austria-Hungary March 3,1894, No.50,260

and No. 79,928, and in Italy August 10, 1896, No. 13,688.

To all whom it may concern.-

Be it known that I, FRIEDRICH WILHELM KLEVER, a subject of the German Emperor, and a resident of Cologne, in the German Empire, have invented certain new and useful Improvements in the Manufacture of Solutions of Medicinal Preparations in a Liquid Prepared from Mineral Oils, (for which patents have been obtained in Great Britain, No. 12,446, dated June 24, 1893, and No. 5,256, dated February 26, 1897; in Belgium, No. 105,269, dated June 26, 1893; in Austria-Hungary, No. 50,260 and No. 79,928, dated March 3, 1894, and in Italy, No. 13,688, dated August 10, 1896,) of which the following is a specification.

This invention relates to a process for renderin g in edicinal preparations which by themselves are insoluble in mineral oils soluble in the latter and to impart thereto the property of forming emulsions with the secretions of the skin or of wounds. At the same time the property is imparted to the medicines of being absorbable by the skin, which has not been hitherto accomplished, while in addition any caustic properties that may be possessed by the medicines are either completely neu-V tralized or reduced in a very great degree.

The medicines whose solution in mineral The process is carried out in the following manner: The mineral oil to be treated is mixed with oxygen carriers in particular alkalies, of which there are preferably used caustic alkalies or alkaline carbonates either in the solid form or in solution, in which latter case the solutions are advantageously made as concentrated as possible. The mixture is heated in a pan, if necessary, under stirring, while at the same time oxygen in pressure. If pure oxygen is employed, it is advisable to employ the compressed gas of commerce.

any form is introduced, if necessary, under The quantity of caustic alkalies H to be added may vary between two and seven 'per cent. of sodium or potassium hydroiiid.

It is of advantage to choose Many mineral oils cannot be brought into the requisite form for the before-mentioned purpose by the above-described treatment.

In such cases it is advisable to add some fatty oils or fatty acids to the mineral oils treated With the alkalies. Such mineral oils are taken with advantage in which the addition of fatty oils or fatty acids need not exceed twenty per cent.

lVith mineral oils to which fatty oils or fatty acids have been added it is advisable instead of adding pure caustic alkalies or pure solutions thereof to employ an addition of ammonia or an addition of this together with the other alkalies in the above stated proportions.

In order to avoid too great viscosity of the finished product, an addition of alcohol up to two per cent. is permissible.

The quantity'of the necessary additions,

the duration of the heating, and the necessary pressure will vary according to the na ture of the oils employed. The necessary pressure varies according to the nature of the mineral oils Within wide limits, such as between seven to thirty atmospheres.

The temperature can be raised up to 200 centigrade. The proportions must be so chosen that the product obtained forms an emulsion with water, which is determined by taking a sample and testing its behavior 5 with water.

Sometimes the combination of the oxygen with the mineral oils mixed with fatty oils or fatty acids can be eifected by simply shak= ing together with air after the said additions have been made. Of the mineral oils the socalled heavy oils of the specific gravity of 0.890 and 0.900, as also the purified paraffin-oils, and the so-callec Vaseline-oils have been found suitable for the purpose of this invention.

The solution of the medicinal compounds in the vasogenes is effected in the known manner by digestion and the like, if necessary under pressure, under the above-named conditions. Of the substances which when dissolved in vasogen show the above-described properties of forming an emulsion and becoming absorbed the following proportions of solution are employed: iodin, one to six to twenty per cent; iodoform, one and onehalf per cent. ichthyol, ten to fifty per cent. euealyptol, twenty per cent; turpentine, twenty per cent; creosote, twenty to fifty per cent. guaiacol, twenty to fifty per cent. creolin, five to fifty per cent; pyoctanin, two per cent.

Chloroforrncamphor is soluble in equal proportions, while menthol can be dissolved in any desired proportions.

If it is desired to make a salve, then from three to ten per cent. of oxygenated Vaseline prepared as described is mixed with the usual salve bases, such as wax or ceresin.

Having now particularly described and ascertained the nature of my invention and the manner in which the same is to be performed, I declare that what I claim is 1.. A process for preparing solutions in mineral oils of substances insoluble therein, which consists in mixing an alkali with the mineral oil, oxidizing the mixture and adding thereto the substance to be dissolved.

2. A process for preparing solutions in mineral oils of substances insoluble therein, which consists in mixing a fatty body and an alkali with the mineral oil, oxidizing the mixture, and adding thereto the substance to be dissolved.

3. A process for preparing solutions in mineral oils of substances insoluble therein, which consists in mixing a fatty acid and an alkali with the mineral oil, oxidizing the mixture and adding thereto the substance to be dissolved.

4:. A process for preparing solutions in mineral oils of substances insoluble therein, which consists in mixing an alkali with a heavy mineral oil (Vaseline-oil) oxidizing the mixture, and adding thereto the substance to be dissolved.

5. As a new article of manufacture, a composition of matter consisting of an oxidized mineral oil and a remedial agent normally insoluble in said oil, held in solution therein, substantially as and for the purpose set forth.

Signed at Cologne, in the German Empire, this 24th day of November, 1807.

FRIEDRICH WILHELM K LEVER.

\Vitnesses:

FRANZ GREIN, WILLIAM H. MADDEN. 

